Human Gene GBF1 (ENST00000677618.1_2) from GENCODE V45lift37
| Description: hom*o sapiens golgi brefeldin A resistant guanine nucleotide exchange factor 1 (GBF1), transcript variant 7, mRNA. (from RefSeq NM_001377140) RefSeq Summary (NM_001377140): This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]. Gencode Transcript: ENST00000677618.1_2 Gencode Gene: ENSG00000107862.7_16 Transcript (Including UTRs) Position:hg19 chr10:104,005,278-104,142,642Size:137,365Total Exon Count:38Strand:+ Coding Region Position:hg19 chr10:104,018,696-104,142,093Size:123,398Coding Exon Count:37
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Sequence and Links to Tools and Databases
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Primer design for this transcript
Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA. Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3 |
MalaCards Disease Associations
| MalaCards Gene Search: GBF1 Diseases sorted by gene-association score: legionnaires' disease (5), heterotopia, periventricular (5) |
Common Gene Haplotype Alleles mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have. | |||||||||||||||||||||||
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Descriptions from all associated GenBank mRNAs
| LF385292 - JP 2014500723-A/192795: Polycomb-Associated Non-Coding RNAs. BC094763 - hom*o sapiens golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1, mRNA (cDNA clone IMAGE:30528881), complete cds. AK025330 - hom*o sapiens cDNA: FLJ21677 fis, clone COL09171, highly similar to AF068755 hom*o sapiens sec7 domain family member (GBF1) mRNA. BC032543 - hom*o sapiens golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1, mRNA (cDNA clone IMAGE:5535398), partial cds. AF068755 - hom*o sapiens sec7 domain family member (GBF1) mRNA, complete cds. D87435 - hom*o sapiens mRNA for KIAA0248 gene. BC117681 - hom*o sapiens golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1, mRNA (cDNA clone MGC:134877 IMAGE:40070852), complete cds. BC117682 - hom*o sapiens golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1, mRNA (cDNA clone MGC:134878 IMAGE:40070853), complete cds. AB383818 - Synthetic construct DNA, clone: pF1KSDA0248, hom*o sapiens GBF1 gene for Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1, complete cds, without stop codon, in Flexi system. MA620869 - JP 2018138019-A/192795: Polycomb-Associated Non-Coding RNAs. BC057804 - hom*o sapiens cDNA clone IMAGE:30345987. BC068543 - hom*o sapiens cDNA clone IMAGE:30345986. JD055124 - Sequence 36148 from Patent EP1572962. JD148104 - Sequence 129128 from Patent EP1572962. JD073373 - Sequence 54397 from Patent EP1572962. JD107807 - Sequence 88831 from Patent EP1572962. JD478990 - Sequence 460014 from Patent EP1572962. JD464854 - Sequence 445878 from Patent EP1572962. LF345838 - JP 2014500723-A/153341: Polycomb-Associated Non-Coding RNAs. LF211353 - JP 2014500723-A/18856: Polycomb-Associated Non-Coding RNAs. LF345840 - JP 2014500723-A/153343: Polycomb-Associated Non-Coding RNAs. LF345841 - JP 2014500723-A/153344: Polycomb-Associated Non-Coding RNAs. LF345843 - JP 2014500723-A/153346: Polycomb-Associated Non-Coding RNAs. AK024916 - hom*o sapiens cDNA: FLJ21263 fis, clone COL01565, highly similar to AF068755 hom*o sapiens sec7 domain family member (GBF1) mRNA. LF345844 - JP 2014500723-A/153347: Polycomb-Associated Non-Coding RNAs. LF345845 - JP 2014500723-A/153348: Polycomb-Associated Non-Coding RNAs. LF345846 - JP 2014500723-A/153349: Polycomb-Associated Non-Coding RNAs. AK025153 - hom*o sapiens cDNA: FLJ21500 fis, clone COL05639, highly similar to AF068755 hom*o sapiens sec7 domain family member (GBF1) mRNA. LF345847 - JP 2014500723-A/153350: Polycomb-Associated Non-Coding RNAs. BC014171 - hom*o sapiens golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1, mRNA (cDNA clone IMAGE:4561065), partial cds. LF345849 - JP 2014500723-A/153352: Polycomb-Associated Non-Coding RNAs. BC007941 - hom*o sapiens golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1, mRNA (cDNA clone IMAGE:4131763), partial cds. LF345850 - JP 2014500723-A/153353: Polycomb-Associated Non-Coding RNAs. LF345851 - JP 2014500723-A/153354: Polycomb-Associated Non-Coding RNAs. LF345852 - JP 2014500723-A/153355: Polycomb-Associated Non-Coding RNAs. JD084671 - Sequence 65695 from Patent EP1572962. JD319935 - Sequence 300959 from Patent EP1572962. JD338397 - Sequence 319421 from Patent EP1572962. JD327125 - Sequence 308149 from Patent EP1572962. JD172992 - Sequence 154016 from Patent EP1572962. JD173272 - Sequence 154296 from Patent EP1572962. JD080680 - Sequence 61704 from Patent EP1572962. JD529872 - Sequence 510896 from Patent EP1572962. JD514634 - Sequence 495658 from Patent EP1572962. JD072602 - Sequence 53626 from Patent EP1572962. JD492943 - Sequence 473967 from Patent EP1572962. JD376948 - Sequence 357972 from Patent EP1572962. JD156227 - Sequence 137251 from Patent EP1572962. JD535488 - Sequence 516512 from Patent EP1572962. JD187293 - Sequence 168317 from Patent EP1572962. JD111642 - Sequence 92666 from Patent EP1572962. JD551868 - Sequence 532892 from Patent EP1572962. JD253892 - Sequence 234916 from Patent EP1572962. JD301626 - Sequence 282650 from Patent EP1572962. JD299648 - Sequence 280672 from Patent EP1572962. MA581415 - JP 2018138019-A/153341: Polycomb-Associated Non-Coding RNAs. MA581417 - JP 2018138019-A/153343: Polycomb-Associated Non-Coding RNAs. MA581418 - JP 2018138019-A/153344: Polycomb-Associated Non-Coding RNAs. MA581420 - JP 2018138019-A/153346: Polycomb-Associated Non-Coding RNAs. MA581421 - JP 2018138019-A/153347: Polycomb-Associated Non-Coding RNAs. MA581422 - JP 2018138019-A/153348: Polycomb-Associated Non-Coding RNAs. MA581423 - JP 2018138019-A/153349: Polycomb-Associated Non-Coding RNAs. MA581424 - JP 2018138019-A/153350: Polycomb-Associated Non-Coding RNAs. MA581426 - JP 2018138019-A/153352: Polycomb-Associated Non-Coding RNAs. MA581427 - JP 2018138019-A/153353: Polycomb-Associated Non-Coding RNAs. MA581428 - JP 2018138019-A/153354: Polycomb-Associated Non-Coding RNAs. MA581429 - JP 2018138019-A/153355: Polycomb-Associated Non-Coding RNAs. MA446930 - JP 2018138019-A/18856: Polycomb-Associated Non-Coding RNAs. |
Biochemical and Signaling Pathways
| BioCarta from NCI Cancer Genome Anatomy Project h_arapPathway - ADP-Ribosylation Factor |
