Human Gene H1-10 (ENST00000333762.6_5) from GENCODE V45lift37
| Description: hom*o sapiens H1.10 linker histone (H1-10), mRNA. (from RefSeq NM_006026) RefSeq Summary (NM_006026): Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]. Gencode Transcript: ENST00000333762.6_5 Gencode Gene: ENSG00000184897.7_9 Transcript (Including UTRs) Position:hg19 chr3:129,033,614-129,035,129Size:1,516Total Exon Count:1Strand:- Coding Region Position:hg19 chr3:129,034,104-129,034,745Size:642Coding Exon Count:1
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
| ID: H1X_HUMAN DESCRIPTION: RecName: Full=Histone H1x; FUNCTION: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. SUBCELLULAR LOCATION: Nucleus. Chromosome. TISSUE SPECIFICITY: Expressed ubiquitously. SIMILARITY: Belongs to the histone H1/H5 family. SIMILARITY: Contains 1 H15 (linker histone H1/H5 globular) domain. |
Primer design for this transcript
Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA. Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3 |
Common Gene Haplotype Alleles RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
| Highest median expression: 142.74 RPKM in Skin - Not Sun Exposed (Suprapubic) Total median expression: 3757.00 RPKM
View in GTEx track of Genome BrowserView at GTEx portalView GTEx Body Map |
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have. | |||||||||||||||||||||||
Protein Domain and Structure Information
| InterPro Domains: Graphical view of domain structure IPR005818 - Histone_H1/H5 IPR005819 - Histone_H5 IPR011991 - WHTH_trsnscrt_rep_DNA-bd Pfam Domains: SCOP Domains: Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q92522
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
| Molecular Function: GO:0003677 DNA binding GO:0003723 RNA binding GO:0045296 cadherin binding Biological Process: Cellular Component: |
Descriptions from all associated GenBank mRNAs
| BC010435 - hom*o sapiens H1 histone family, member X, mRNA (cDNA clone MGC:15959 IMAGE:3538400), complete cds. LF384151 - JP 2014500723-A/191654: Polycomb-Associated Non-Coding RNAs. D64142 - hom*o sapiens mRNA for histone H1x, complete cds. BC000426 - hom*o sapiens H1 histone family, member X, mRNA (cDNA clone MGC:8350 IMAGE:2819756), complete cds. JD371489 - Sequence 352513 from Patent EP1572962. JD406655 - Sequence 387679 from Patent EP1572962. JD022115 - Sequence 3139 from Patent EP1572962. JD030708 - Sequence 11732 from Patent EP1572962. JD565326 - Sequence 546350 from Patent EP1572962. JD445927 - Sequence 426951 from Patent EP1572962. JD121060 - Sequence 102084 from Patent EP1572962. LF363833 - JP 2014500723-A/171336: Polycomb-Associated Non-Coding RNAs. JD047922 - Sequence 28946 from Patent EP1572962. JD152537 - Sequence 133561 from Patent EP1572962. JD387773 - Sequence 368797 from Patent EP1572962. JD464973 - Sequence 445997 from Patent EP1572962. MA619728 - JP 2018138019-A/191654: Polycomb-Associated Non-Coding RNAs. MA599410 - JP 2018138019-A/171336: Polycomb-Associated Non-Coding RNAs. |
| Alternate Gene Symbols: ENST00000333762.1, ENST00000333762.2, ENST00000333762.3, ENST00000333762.4, ENST00000333762.5, H1FX, H1X_HUMAN, NM_006026, Q92522, uc317ttc.1 UCSC ID: ENST00000333762.6_5 RefSeq Accession: NM_006026 Protein: Q92522 (aka H1X_HUMAN) |
