Human Gene NOLC1 (ENST00000488254.6_6) from GENCODE V45lift37 (2024)

Human Gene NOLC1 (ENST00000488254.6_6) from GENCODE V45lift37

Description: hom*o sapiens nucleolar and coiled-body phosphoprotein 1 (NOLC1), transcript variant 3, mRNA. (from RefSeq NM_001284389)
Gencode Transcript: ENST00000488254.6_6
Gencode Gene: ENSG00000166197.17_13
Transcript (Including UTRs)
Position:hg19 chr10:103,912,161-103,922,357Size:10,197Total Exon Count:13Strand:+
Coding Region
Position:hg19 chr10:103,912,168-103,922,026Size:9,859Coding Exon Count:13

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC:2024-04-24 11:59:55

Sequence and Links to Tools and Databases

Genomic Sequence (chr10:103,912,161-103,922,357)			mRNA (may differ from genome)		Protein (700 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NOLC1_HUMAN DESCRIPTION: RecName: Full=Nucleolar and coiled-body phosphoprotein 1; AltName: Full=140 kDa nucleolar phosphoprotein; Short=Nopp140; AltName: Full=Hepatitis C virus NS5A-transactivated protein 13; Short=HCV NS5A-transactivated protein 13; AltName: Full=Nucleolar 130 kDa protein; AltName: Full=Nucleolar phosphoprotein p130; FUNCTION: Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I. SUBUNIT: Interacts with RNA polymerase I 194 kDa subunit (RPA194) and with casein kinase-II. INTERACTION: P49407:ARRB1; NbExp=3; IntAct=EBI-396155, EBI-743313; P32121:ARRB2; NbExp=3; IntAct=EBI-396155, EBI-714559; P04591:gag (xeno); NbExp=2; IntAct=EBI-396155, EBI-6179719; SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase. PTM: Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. There is evidence suggesting that CDK1 kinase phosphorylates p130 at the M-phase. SIMILARITY: Contains 1 LisH domain.

Primer design for this transcript


	Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA. Click here to load the transcript sequence and exon structure into Primer3Plus Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. Click here to open Exonprimer with this transcript To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: NOLC1 Diseases sorted by gene-association score: hepatitis c virus (2), diffuse gastric cancer (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003993Dibutyl Phthalate D013749Tetrachlorodibenzodioxin C006780bisphenol A C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl C0630022,3-dimethoxy-1,4-naphthoquinone C0109142,4-diaminotoluene C0164032,4-dinitrotoluene C0235142,6-dinitrotoluene C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine C0095054,4'-diaminodiphenylmethane more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 53.72 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 990.34 RPKM View in GTEx track of Genome BrowserView at GTEx portalView GTEx Body Map

Highest median expression: 53.72 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 990.34 RPKM

View in GTEx track of Genome BrowserView at GTEx portalView GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-85.00	331	-0.257	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR006594 - LisH_dimerisation
IPR007718 - SRP40_C

Pfam Domains:
PF05022 - SRP40, C-terminal domain

ModBase Predicted Comparative 3D Structure on Q14978


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0001042 RNA polymerase I core binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003723 RNA binding GO:0005515 protein binding GO:0005524 ATP binding GO:0005525 GTP binding GO:0008134 transcription factor binding GO:0008139 nuclear localization sequence binding GO:0019904 protein domain specific binding GO:0034512 box C/D snoRNA binding GO:0034513 box H/ACA snoRNA binding GO:0046982 protein heterodimerization activity Biological Process: GO:0000278 mitotic cell cycle GO:0006364 rRNA processing GO:0006417 regulation of translation GO:0006970 response to osmotic stress GO:0007000 nucleolus organization GO:0008284 positive regulation of cell proliferation GO:0014029 neural crest formation GO:0014032 neural crest cell development GO:0033979 box H/ACA snoRNA metabolic process GO:0042306 regulation of protein import into nucleus GO:0045893 positive regulation of transcription, DNA-templated Cellular Component: GO:0001650 fibrillar center GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005730 nucleolus GO:0005737 cytoplasm GO:0015030 Cajal body GO:0031428 box C/D snoRNP complex GO:0031429 box H/ACA snoRNP complex GO:0072588 box H/ACA RNP complex

Molecular Function:
GO:0000166 nucleotide binding
GO:0001042 RNA polymerase I core binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0008134 transcription factor binding
GO:0008139 nuclear localization sequence binding
GO:0019904 protein domain specific binding
GO:0034512 box C/D snoRNA binding
GO:0034513 box H/ACA snoRNA binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0000278 mitotic cell cycle
GO:0006364 rRNA processing
GO:0006417 regulation of translation
GO:0006970 response to osmotic stress
GO:0007000 nucleolus organization
GO:0008284 positive regulation of cell proliferation
GO:0014029 neural crest formation
GO:0014032 neural crest cell development
GO:0033979 box H/ACA snoRNA metabolic process
GO:0042306 regulation of protein import into nucleus
GO:0045893 positive regulation of transcription, DNA-templated

Cellular Component:
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0031428 box C/D snoRNP complex
GO:0031429 box H/ACA snoRNP complex
GO:0072588 box H/ACA RNP complex

Descriptions from all associated GenBank mRNAs


	LF211442 - JP 2014500723-A/18945: Polycomb-Associated Non-Coding RNAs. Z34289 - H.sapiens mRNA for nucleolar phosphoprotein p130. AK225101 - homo sapiens mRNA for nucleolar and coiled-body phosphoprotein 1 variant, clone: CAS08881. AK314363 - homo sapiens cDNA, FLJ95131, highly similar to homo sapiens nucleolar and coiled-body phosphoprotein 1 (NOLC1), mRNA. AK056755 - homo sapiens cDNA FLJ32193 fis, clone PLACE6002345, highly similar to Nucleolar phosphoprotein p130. BC001883 - homo sapiens nucleolar and coiled-body phosphoprotein 1, mRNA (cDNA clone MGC:1494 IMAGE:3533568), complete cds. BC006769 - homo sapiens nucleolar and coiled-body phosphoprotein 1, mRNA (cDNA clone MGC:5049 IMAGE:2900024), complete cds. DQ891862 - Synthetic construct clone IMAGE:100004492; FLH180698.01X; RZPDo839F01134D nucleolar and coiled-body phosphoprotein 1 (NOLC1) gene, encodes complete protein. DQ895051 - Synthetic construct homo sapiens clone IMAGE:100009511; FLH180694.01L; RZPDo839F01133D nucleolar and coiled-body phosphoprotein 1 (NOLC1) gene, encodes complete protein. AB383719 - Synthetic construct DNA, clone: pF1KSDA0035, homo sapiens NOLC1 gene for nucleolar phosphoprotein p130, complete cds, without stop codon, in Flexi system. AY820769 - homo sapiens HCV NS5A trans-regulated protein 13 mRNA, complete cds. D21262 - homo sapiens KIAA0035 mRNA, partial cds. LF379634 - JP 2014500723-A/187137: Polycomb-Associated Non-Coding RNAs. LF379636 - JP 2014500723-A/187139: Polycomb-Associated Non-Coding RNAs. LF379638 - JP 2014500723-A/187141: Polycomb-Associated Non-Coding RNAs. LF379639 - JP 2014500723-A/187142: Polycomb-Associated Non-Coding RNAs. L37718 - homo sapiens (clone 17) macronuclear mRNA. L37710 - homo sapiens (clone 34) macronuclear mRNA. LF379640 - JP 2014500723-A/187143: Polycomb-Associated Non-Coding RNAs. CU675459 - Synthetic construct homo sapiens gateway clone IMAGE:100017224 5' read NOLC1 mRNA. KJ901956 - Synthetic construct homo sapiens clone ccsbBroadEn_11350 NOLC1 gene, encodes complete protein. LF379641 - JP 2014500723-A/187144: Polycomb-Associated Non-Coding RNAs. LF379642 - JP 2014500723-A/187145: Polycomb-Associated Non-Coding RNAs. LF379644 - JP 2014500723-A/187147: Polycomb-Associated Non-Coding RNAs. LF379645 - JP 2014500723-A/187148: Polycomb-Associated Non-Coding RNAs. JD518830 - Sequence 499854 from Patent EP1572962. JD496515 - Sequence 477539 from Patent EP1572962. JD259154 - Sequence 240178 from Patent EP1572962. JD219842 - Sequence 200866 from Patent EP1572962. JD051823 - Sequence 32847 from Patent EP1572962. JD347365 - Sequence 328389 from Patent EP1572962. JD042325 - Sequence 23349 from Patent EP1572962. MA447019 - JP 2018138019-A/18945: Polycomb-Associated Non-Coding RNAs. MA615211 - JP 2018138019-A/187137: Polycomb-Associated Non-Coding RNAs. MA615213 - JP 2018138019-A/187139: Polycomb-Associated Non-Coding RNAs. MA615215 - JP 2018138019-A/187141: Polycomb-Associated Non-Coding RNAs. MA615216 - JP 2018138019-A/187142: Polycomb-Associated Non-Coding RNAs. MA615217 - JP 2018138019-A/187143: Polycomb-Associated Non-Coding RNAs. MA615218 - JP 2018138019-A/187144: Polycomb-Associated Non-Coding RNAs. MA615219 - JP 2018138019-A/187145: Polycomb-Associated Non-Coding RNAs. MA615221 - JP 2018138019-A/187147: Polycomb-Associated Non-Coding RNAs. MA615222 - JP 2018138019-A/187148: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000488254.1, ENST00000488254.2, ENST00000488254.3, ENST00000488254.4, ENST00000488254.5, KIAA0035, NM_001284389, NOLC1_HUMAN, NS5ATP13, Q14978, Q15030, Q5VV70, Q9BUV3, uc322iom.1 UCSC ID: ENST00000488254.6_6 RefSeq Accession: NM_001284389 Protein: Q14978 (aka NOLC1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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